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. 2016 Feb 29;5(6):1214–1227. doi: 10.1002/cam4.670

Figure 2.

Figure 2

Host EphA4 deficiency reduced metastasis. (A) tumor metastatic foci in the lung (left) and liver (right) in 46‐day control EphA4‐WT tumor‐bearing mouse in the upper lane, paired EphA4‐KO tumor‐bearing littermate mouse without IGF1 treatment in the middle lane and 46‐day EphA4‐KO tumor‐bearing mouse with IGF1 treatment in the lower lane. (B) statistical analysis showed in the absence of IGF1 treatment, number of metastatic tumor foci were significantly reduced in EphA4‐KO mice compared with control WT tumor‐bearing littermate mice (*P < 0.05; **P < 0.001). When treated with IGF1, EphA4‐KO mice experienced a large increase in the number of metastatic tumors (WT: n = 12; KO: n = 6 of each treatment. Tukey's multiple comparison test).