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. 2016 Apr 5;5(6):1259–1267. doi: 10.1002/cam4.686

Figure 4.

Figure 4

GABABR/NF‐κB signaling pathway regulates the proliferation. (A) Representative picture showed the detection of the influence of baclofen on NF‐κB signaling. (B) MTS proliferation assay showed that the promotion of cells proliferation caused by downregulation of GABABR could be rescued by PDTC meanwhile. Data shown are means ± SD (n = 3). (C) PDTC blocked the promotion of proliferation caused by downregulation of GABABR. Data shown are means ± SD (n = 3). ***P < 0. 001 versus the corresponding control. (D) PDTC restored the cell cycle influence caused by downregulation of GABABR. Data shown are means ± SD (n = 3). (E) PDTC restored the expression of cell cycle‐related genes influenced by GABABR downregulation. Data shown are means ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001 versus the corresponding control.