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. 2016 Jun 28;10:317. doi: 10.3389/fnhum.2016.00317

Figure 1.

Figure 1

Simplified schematic representation of basal ganglia circuitry highlighting cortical and striatal outputs. Open arrows represent excitation, closed arrows represent inhibition. Neurotransmitters are indicated in parenthesis. Intra-telencephalically projecting (IT)-type CPNs project to the striatongiral D1-enriched MSNs of the direct pathway. Pyramidal tract (PT)-type CPNs project to the stratopallidal D2-enriched MSNs of the indirect pathway. Abbreviations: Glu, glutamate; enk, enkephalin; subst P, substance P.