Figure 5.

(A) Schematic illustration of the fabrication of PIC ^⊕NP/Pt@PPC-DA pH-responsive nanoparticles; (B) Schematic illustration of the procedure of drug release from polymer nanoparticles. (i) non-specific interactions are scarcely happened between ^⊕NP/Pt@PPC-DA and serum components; (ii) nanoparticles accumulate at the tumor site owing to the enhanced permeability and retention effect; (iii) the positively charged ^⊕NP/Pt nanoparticles are exposed again to enhance the Pt(IV) pro-drug internalization; (iv) the Pt(IV) pro-drug is rapidly released from ^⊕NP/Pt nanoparticles. Reproduced with permission from reference ⁹¹.