Figure 7.

A) Automated and modular synthesis of ApDCs from phosphoramidites A, T, C, G and D (top); Structural features of phosphoramidite D (bottom). Reprinted (adapted) with permission from ref. 31. Copyright (2014) American Chemical Society. B) Schematic illustration of nuclease-resistant synthetic drug-DNA adducts as a simple, yet versatile and programmable, platform for targeted anticancer drug delivery. Adapted by permission from Macmillan Publishers Ltd: [NPG Asia Materials] (ref.³²), copyright (2015).