Table 1. COMT SNPs and coded allele frequencies in each of the study cohorts. Allele frequencies from the 1000 Genomes are included as a reference.
| Study | Study type | Cohort | N | Coded allele frequency |
||
|---|---|---|---|---|---|---|
| Rs4680 | Rs4633 | Rs4818 | ||||
| WGHS | RCT | Unselected (women) | 23,294 | G (0.46) | C (0.46) | G (0.39) |
| MAGIC | GWAS meta-analysis | Unselected cohorts | 46,368 | G (0.52) | C (0.52) | G (†) |
| DIAGRAM | GWAS meta-analysis | Impaired glucose function | 82,085 | G (†) | C (†) | C (†) |
| DPP | RCT | Unselected cohorts | 2714 | G (0.56) | C (0.55) | † |
| 1000 Genomes 1 | G (0.63) | C (0.63) | G (0.70) | |||
†
Data not available in database.
1
Genomes Project C, Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, et al. An integrated map of genetic variation from 1092 human genomes. Nature. 2012;491:56–65.