Table 3. Age-adjusted Cox proportional hazard models of COMT rs4680, rs4633, rs4818 effects on HbA1c in the WGHS adjusted for obesity (BMI >30), systolic blood pressure (SBP) or triglycerides.
Rs4680 |
Rs4633 |
Rs4818 |
||||
---|---|---|---|---|---|---|
β [SE] | p | β [SE] | p | β [SE] | p | |
Age-adjusted | −0.031 [0.012] | 0.008 | −0.034 [0.012] | 0.005 | −0.029 [0.012] | 0.02 |
BMI > 30 | −0.030 [0.012] | 0.01 | −0.033 [0.012] | 0.006 | −0.028 [0.012] | 0.02 |
SBP | −0.027 [0.012] | 0.02 | −0.030 [0.012] | 0.01 | −0.025 [0.012] | 0.04 |
Triglycerides | −0.023 [0.010] | 0.03 | −0.024 [0.010] | 0.02 | −0.018 [0.010] | 0.09 |
Fully-adjusted | −0.020 [0.010] | 0.05 | −0.022 [0.010] | 0.04 | −0.015 [0.011] | 0.16 |