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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Metabolism. 2016 Apr 14;65(7):961–967. doi: 10.1016/j.metabol.2016.04.001

Table 5. Meta-analysis of COMT SNP association with type 2 diabetes in WGHS, DIAGRAM and DPP.

Study Rs4680*
 Rs4633*
 Rs4818*
HR [95% CI],
p-value		 HR [95% CI],
p-value		 HR [95% CI],
p-value
WGHS 0.92 [0.84–1.00],
 p = 0.06		 0.91 [0.84–1.00],
 p = 0.05		 0.89 [0.81–0.98],
 p = 0.017
DIAGRAM 0.98 [0.96–1.01],
 p = 0.12		 0.98 [0.96–1.01],
 p = 0.13		 0.94 [0.88–1.01],
 p = 0.035
DPP 0.95 [0.84–1.06],
 p = 0.35		 0.96 [0.84–1.09],
 p = 0.51		 Not available
Fixed 0.98 [0.96–0.998],
 p = 0.03		 0.98 [0.96–1.00],
 p = 0.04		 0.92 [0.87–0.98],
 p = 0.005
*

Rs4680 coded allele = G(val), reference allele = A(met); rs4633 coded allele = C, reference allele = T; rs4818 coded allele = G, reference allele = C.