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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Metabolism. 2016 Apr 14;65(7):961–967. doi: 10.1016/j.metabol.2016.04.001

Table 7. COMT association with treatment response to metformin in the DPP and aspirin in the WGHS.

Study SNP HR [95% CI],
p-value		 HR [95% CI],
p-value		 p Interaction
DPP Metformin (n = 896) Placebo (n = 909)
Rs4680 0.81 [0.65–1.00],
 p = 0.05		 0.99 [0.82–1.18],
 p = 0.90		 0.16
Rs4633 0.76 [0.60–0.97],
 p = 0.03		 1.02 [0.84–1.23],
 p = 0.90		 0.11
WGHS Aspirin (n = 5812) Placebo (n = 5811)
Rs4680 0.87 [0.73–1.04],
 p = 0.12		 1.05 [0.87–1.25],
 p = 0.60		 0.15
Rs4633 0.88 [0.73–1.05],
 p = 0.16		 1.05 [0.88–1.26],
 p = 0.60		 0.14
Rs4818 0.88 [0.74–1.05],
 p = 0.16		 1.01 [0.83–1.21],
 p = 0.90		 0.30