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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2016 Apr 27;172(2):138–145. doi: 10.1002/ajmg.c.31484

Figure 1.

Figure 1

Nipbl-deficient mutant animals show growth abnormalities. (A) Nipbl+/− mouse is markedly smaller than wildtype (+/+) sibling at 4 weeks of age. (B) Nipbl a+b morpholino (MO) co-injected zebrafish larvae (nipbl a/b morphants) resemble uninjected and mixed MO controls at 18.5 hr post-fertilization (hpf), but show marked circulatory defects, pericardial edema (asterisk) and tail defects (arrowheads) by 34 hpf. Scale bar ¼ 100 mm. (C) Structural comparison of NIPBL orthologues among different species. H.s., Homo sapiens, 2,804 amino acids (aa).; M.m., Mus musculus, 2,798 aa; D.r. (a), Danio rerio, form a, 2,876 aa; D.r. (b), form b, 2,381 aa; D.m., Drosophila melanogaster, 2,077 aa; S.c., Saccharomyces cerevisiae, 1,493 aa. Numbers indicate percent amino acid sequence identity compared to human NIPBL. Adapted from [Kawauchi et al., 2009; Muto et al., 2011].