Table 5.
Antimicrobial Activity of organic extracts from leaves and roots of C. spinosa against Candida spp.
| C. spinosa | Candida albicans | Candida glabrata | Candida krusei | Candida parapsilosis | Candida tropicalis | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Extracts | MIC | MMC | MIC | MMC | MIC | MMC | MIC | MMC | MIC | MMC |
| ChL | 12.5 | 12.5 | 3.12 | 25 | 12.5 | 25 | 6.25 | 25 | 6.25 | 50 |
| CL | 3.12 | 12.5 | 3.12 | 50 | 12.5 | 25 | 3.12 | 12.5 | 3.12 | 50 |
| EAL | 6.25 | 12.5 | 3.12 | 25 | 12.5 | 25 | 6.25 | 12.5 | 6.25 | 50 |
| ML | 6.25 | 12.5 | 6.25 | 25 | 12.5 | 25 | 6.25 | 6.25 | 3.12 | 50 |
| ChR | 12.5 | 25 | 6.25 | 25 | 6.25 | 25 | 6.25 | 25 | 12.5 | 12.5 |
| CR | 12.5 | 50 | 12.5 | >50 | 6.25 | 25 | 6.25 | 25 | 12.5 | 50 |
| EAR | 12.5 | 12.5 | 12.5 | 25 | 12.5 | 25 | 6.25 | 12.5 | 12.5 | 25 |
| MR | 12.5 | 12.5 | 12.5 | 50 | 6.25 | 25 | 6.25 | 25 | 6.25 | 25 |
| Control | MIC | MIC | MIC | MIC | MIC | |||||
| FLU | 0.0005 | 0.001 | 0.002 | 0.002 | 0.001 | |||||
| ITCZ | 0.00003 | 0.00012 | 0.00006 | 0.00006 | 0.00006 | |||||
| AMP-B | 0.002 | 0.00025 | 0.00012 | 0.001 | 0.001 | |||||
MIC, Minimal Inhibitory Concentration; MMC, Minimal Microbicidal Concentration; MIC and MMC values are expressed in mg/mL. Cyclohexane extracts, ChL and ChR; chloroform extracts, CL and CR; ethyl acetate extracts, EAL and EAR; methanolic extracts, ML and MR.
FLU, fluconazole; ITCZ, itraconazole; AMP-B, amphotericin B.