TABLE 7.

Sensitivities, specificities, and thresholds for distinguishing binary DEFC score (no/mild symptoms vs. debilitating symptoms)

Diagnostic	Threshold	Sensitivity (95% CI)	Specificity (95% CI)
NITBUT	11.0 s	0.72 (0.62–0.83)	0.52 (0.40–0.64)
FTBUT	8.7 s	0.68 (0.57–0.79)	0.57 (0.45–0.69)
Osmolarity	294 mOsm/L	0.67 (0.56–0.76)	0.46 (0.34–0.58)
Corneal staining Hx	Present at >20% of visits	0.29 (0.19–0.40)	0.83 (0.74–0.92)
DE severity (0–100)
Average	16	0.81 (0.71–0.90)	0.71 (0.60–0.82)
End of day	31	0.79 (0.70–0.86)	0.80 (0.70–0.90)
DE frequency (0–100)
Average	16	0.74 (0.63–0.84)	0.78 (0.68–0.88)
End of day	19	0.85 (0.76–0.93)	0.71 (0.60–0.82)

CI, confidence interval; Hx, history.