Table 1. Antiparasitic Activities of Natural and Synthetic Phloroglucinols and Analogues.
compound number (this work) | IC50 (μM) Dd2 strain | compound number (ref (8)) | IC50 (μM) FcB1/Columbia strain |
---|---|---|---|
1 | 0.64 ± 0.1a | 2 | 0.75 ± 0.11 |
5 | 8.1 ± 0.8 | 5a | 17.6 ± 4.3 |
6 | 1.7 ± 0.8 | 12 | 6 ± 0.4 |
7 | >10 | NRb | |
8 | >20 | NR | |
9 | >10 | NR | |
10 | >20 | NR | |
11 | 1.7 ± 0.4 | 6 | 7.4 ± 1.1 |
12 | 0.57 ± 0.09 | 7 | 4.4 ± 1.3 |
13 | 0.56 ± 0.07 | NR | |
14 | >20 | NR | |
15 | >20 | NR | |
16 | >20 | NR | |
17 | 6.6 ± 2.4 | NR | |
18 | 3.6 ± 0.8 | NR |