Table 2.
Comorbid conditions and comedications at time of event in two nested case-control studies. Differences in comorbid conditions and comedications between outcome groups, combined with data on degree of alendronate exposure, drive conditional logistic regression analyses in subsequent tables. Figures are numbers (percentage) of patients unless specified otherwise
| Subtrochanteric and femoral shaft fracture | Hip fracture | ||||||
|---|---|---|---|---|---|---|---|
| Cases (n=1428) | Controls (n=6825) | P value | Cases (n=6784) | Controls (n=19 952) | P value | ||
| Mean (SD) age (years) | 79.6 (9.4) | 79.7 (9.4) | NA* | 80.2 (8.9) | 80.1 (8.8) | NA* | |
| Women | 1258 (88.1) | 6056 (88.7) | NA* | 5980 (88.1) | 17 605 (88.1) | NA* | |
| Charlson index: | |||||||
| 0 | 409 (28.6) | 2530 (37.1) | <0.001 | 2092 (30.8) | 7504 (37.6) | <0.001 | |
| 1 | 102 (7.1) | 442 (6.5) | 514 (7.6) | 1475 (7.4) | |||
| 2 | 323 (22.6) | 1593 (23.3) | 1485 (21.9) | 4573 (22.9) | |||
| ≥3 | 594 (41.6) | 2260 (33.1) | 2693 (39.7) | 6400 (32.1) | |||
| Main comorbid conditions: | |||||||
| Any fracture | 1091 (76.4) | 3447 (50.5) | <0.001 | 4287 (63.4) | 9061 (45.9) | <0.001 | |
| Major osteoporotic fracture | 987 (69.1) | 2967 (43.5) | <0.001 | 3778 (55.8) | 7709 (39.1) | <0.001 | |
| Fracture of pelvis, femur, or lower leg | 364 (25.5) | 1034 (15.2) | <0.001 | 1260 (18.6) | 2547 (12.9) | <0.001 | |
| Diabetes | 125 (8.8) | 400 (5.9) | <0.001 | 496 (7.3) | 1204 (6.1) | <0.001 | |
| Chronic kidney disease | 25 (1.8) | 74 (1.1) | 0.04 | 125 (1.8) | 248 (1.3) | <0001 | |
| Chronic pulmonary disease | 325 (22.8) | 1382 (20.2) | 0.03 | 1497 (22.1) | 4001 (20.3) | 0.001 | |
| Previous myocardial infarction | 144 (10.1) | 541 (7.9) | 0.008 | 648 (9.6) | 1726 (8.7) | 0.04 | |
| Drug history (in past year): | |||||||
| Prednisolone | 252 (17.6) | 1336 (19.6) | 0.10 | 1255 (18.5) | 4146 (20.8) | <0.001 | |
| Proton pump inhibitors | 483 (33.8) | 1948 (28.5) | <0.001 | 2226 (32.8) | 5488 (27.5) | <0.001 | |
| Thiazides | 350 (24.5) | 1751 (25.7) | 0.38 | 1762 (26.0) | 5187 (26.0) | 0.97 | |
*Age and sex matched analysis, P values not calculated.