Table 4.
Comparison of MAFs of SNPs in the arcOGEN and WTCCC2 cohortsa
| Chr. | SNP | MAF in arcOGEN cases (n = 5,283) | MAF in WTCCC2 controls (n = 4,766) | OR (95% CI) |
|---|---|---|---|---|
| 1 | rs10489912 | 0.42 | 0.42 | 1.01 (0.96–1.07) |
| 1 | rs2249707 | 0.31 | 0.31 | 1.00 (0.94–1.06) |
| 2 | rs888427 | 0.36 | 0.36 | 1.02 (0.96–1.08) |
| 2 | rs10181656 | 0.23 | 0.22 | 1.04 (0.98–1.11) |
| 4 | rs6533712 | 0.48 | 0.47 | 1.04 (0.99–1.10) |
| 5 | rs71624119 | 0.24 | 0.24 | 1.02 (0.95–1.09) |
| 5 | rs528092 | 0.33 | 0.33 | 1.00 (0.95–1.06) |
| 6 | rs10440835 | 0.34 | 0.33 | 1.03 (0.97–1.09) |
| 8 | rs4840565 | 0.28 | 0.27 | 1.02 (0.96–1.08) |
| 8b | rs4736558 | 0.24 | 0.23 | 1.09 (1.02–1.16) |
| 11 | rs613587 | 0.30 | 0.29 | 1.04 (0.97–1.10) |
| 16 | rs28698667 | 0.41 | 0.42 | 0.98 (0.93–1.04) |
| 17 | rs2689 | 0.49 | 0.48 | 1.02 (0.96–1.08) |
| 18 | rs16955629 | 0.24 | 0.24 | 1.02 (0.96–1.09) |
| 21 | rs9979383 | 0.38 | 0.37 | 1.01 (0.95–1.07) |
a
WTCCC2 = Wellcome Trust Case Control Consortium 2; Chr. = chromosome; OR = odds ratio; 95% CI = 95% confidence interval.
b
The single‐nucleotide polymorphism (SNP) rs4736558 on chromosome 8 was the only SNP that showed any difference in minor allele frequency (MAF) (uncorrected P value = 0.010) and was excluded from the analysis.