Skip to main content
. Author manuscript; available in PMC: 2017 Mar 23.
Published in final edited form as: J Am Chem Soc. 2016 Mar 9;138(11):3655–3658. doi: 10.1021/jacs.6b01078

Table 1.

Selected optimization experiments in the enantioselective iridium catalyzed reductive coupling of allylic acetate 1a with formaldehyde illustrating the importance of NMO.a

graphic file with name nihms796355f4.jpg
a

Yields are of material isolated by silica gel chromatography. Enantioselectivities were determined by chiral stationary phase HPLC analysis. See Supporting Information for further experimental details

b

Microwave heating, 6h.