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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Dec 8;1863(3):490–498. doi: 10.1016/j.bbamcr.2015.11.037

Fig. 3. Mice carrying high bone mass Lrp5 gain-of-function mutations have normal hematopoiesis.

Fig. 3

A) Representative flow plots of LSK cells (defined as Lin− Sca-1+ c-Kit+), B) within the LSK gate (right upper gate on A), multipotent progenitor (MMP, CD48+ CD150−), long- and short-term hematopoietic stem cells (LT-HSC, CD48− CD150+; ST-HSC, CD48− CD150−), C) within the Lin− Sca-1− c-Kit+ gate (upper left gate on A), progenitor cells (CMP, FcϒII/IIIRlow CD34+; GMP, FcϒII/IIIRhigh CD34+ and MEP, FcϒII/IIIR− CD34−). D) Within the Lin− Sca-1low c-kitlow cells, common lymphoid progenitors (CLP, Flt3+ IL7R+) and E) within the CD45+ leukocytes, myeloid (CD11b+ Gr1+) and erythroid (CD71+ Ter119+) populations in the BM of Lrp5A/A, Lrp5A/+, and matched WT mice. Right graphs show percentage of the indicated BM cells in WT (n = 3), Lrp5A/+ (n = 7), and Lrp5A/A (n = 7) mice. GMP: granulocyte/monocyte progenitors, CMP: common myeloid progenitor, MEP: megakaryocyte/erythroid progenitor.