Table 2.
Cognitive data at baseline and 1 year follow-up evaluation.
| All 4R tau (n=12)
|
PSP (n=5)
|
CBD (n=7)
|
||||
|---|---|---|---|---|---|---|
| Baseline | Follow-up | Baseline | Follow-up | Baseline | Follow-up | |
|
| ||||||
| MMSE | 27 (23–30) | 23 (15–29)1x | 28 (24–30) | 23 (18–29)y | 27 (23–29) | 23.5 (15–26)1x |
| Digits Backward | 3 (2–6) | 3 (0–6)1 | 3 (2–6) | 3 (0–6) | 3 (3–4) | 3 (0–3)1 |
| Benson figure copy | 15 (13–17) | 16 (9–17)3 | 15 (13–16) | 16 (9–17) | 15 (13–17) | 15.5 (14–17)3 |
| Benson figure recall | 11.5 (3–17) | 9 (5–16)3 | 10 (3–13) | 8 (5–13) | 12 (9–17) | 9.5 (7–16)3 |
|
| ||||||
| AOS (MSE, 7) | 2 (1–4) | 4 (1–7)3x | 1 (1–4) | 4.5 (1–7)1 | 2 (1–4) | 4 (3–7)2x |
| Dysarthria (MSE, 7) | 2 (0–7) | 5 (0–7)3y | 4 (2–7) | 5.5 (2–7)1 | 1 (0–4) | 2 (0–7)2 |
| Speech fluency (WAB, 10) | 9 (5–10) | 5 (1–9)2x | 9 (6–9) | 5.5 (1–9)1 | 9 (5–10) | 4.5 (2–9)1x |
| Information content (WAB, 10) | 10 (5–10) | 8 (4–10)2x | 10 (5–10) | 5.5 (4–10)1 | 10 (9–10) | 9 (5–9)1x |
| Sequential commands (WAB, 80) | 75.5 (61–80) | 78 (54–80)2 | 80 (69–80) | 78 (66–80)1 | 72 (61–80) | 77.5 (54–80)1 |
| Grammar comprehension (%) | 86.5 (74–100) | 73 (58–98)2x | 98 (80–100) | 80 (73–94)1y | 81 (74–98) | 71 (58–98)1y |
| Repetition (WAB, 100) | 88 (52–100) | 70.5 (12–98)2x | 95 (52–100) | 58 (23–98)1y | 88 (64–100) | 71 (12–98)1 |
| Word recognition (WAB, 60) | 60 (59–60) | 59 (58–60)2x | 60 (59–60) | 59 (58–60)1 | 60 (60–60) | 59 (58–60)1x |
| BNT (15) | 13.5 (11–15) | 12 (7–15)1x | 12 (11–15) | 12 (10–15) | 14 (11–15) | 11.5 (7–14)1 |
| Phonemic fluency | 5 (2–13) | 3.5 (1–13)2 | 5 (2–13) | 5 (1–13) | 5 (3–6) | 3 (2–9)2 |
| Semantic fluency | 10 (6–22) | 6.5 (1–20)2x | 9 (6–22) | 8 (1–20)x | 11 (6–13) | 5 (2–10)2x |
1
missing one case,
2
missing two cases,
3
missing three cases.
Longitudinal within group comparison:
x
Baseline vs Follow-up significant at p<0.05;
y
Baseline vs Follow-up trend at p<0.10;
Cross-sectional comparison between groups at time-point 2: Indented = p<0.05 vs Controls at follow-up. PSP and CBD did not differ significantly in any measure at time-point 2 when compared directly. Kruskal-Wallis and post-hoc Mann-Whitney U tests performed.