Table 3. Neurological symptoms and signs at presentation, 1 year, >1 year follow-up evaluations and overall.
Number of cases that reported or presented each symptom or sign. Percentages in parenthesis.
| SYMPTOMS | Presentation | 1yr follow-up | >1yr follow-up | |||
|---|---|---|---|---|---|---|
| psp (n=5) | cbd (n=9) | psp (n=5) | cbd (n=6) | psp (n=4) | cbd (n=5) | |
|
| ||||||
| Swallowing complaints | 3 (60) | 1 (11) | 5 (100)a | 1 (17) | 4 (100) | 4 (80) |
| Reduced manual dexterity | 2 (40) | 2 (22) | 4 (80) | 2 (33) | 4 (100) | 3 (60) |
| Gait/Balance | 3 (60)a | 0 (0) | 3 (60) | 1 (17) | 4 (100) | 3 (60) |
| Falls | 2 (40)a | 0 (0) | 3 (60) | 0 (0) | 4 (100) | 2 (40) |
| Incontinence | 0 (0) | 0 (0) | 2 (40) | 0 (0) | 3 (80) | 1 (20) |
| Impulsive | 1 (20) | 4 (44) | 2 (40) | 5 (83) | 2 (40) | 5 (100) |
| Obsessive/Compulsive | 1 (20) | 2 (22) | 1 (20) | 2 (33) | 1 (20) | 3 (60) |
|
| ||||||
| SIGNS | ||||||
|
| ||||||
| Ocular movements* | 2 (40) | 1 (11) | 5 (100)a | 1 (17) | 4 (100) | 4 (80) |
| -Vertical movements worseˆ | 1 (20) | 0 (0) | 4 (80)a | 1 (17) | 4 (100) | 2 (40) |
| Buccofacial apraxia | 4 (80)a | 0 (0) | 5 (100) | 3 (50) | 4 (100) | 3 (60) |
| Asymmetric limb rigidity | 2 (40) | 2 (22) | 4 (80) | 2 (33) | 4 (100) | 3 (60) |
| Axial rigidity | 3 (60)a | 0 (0) | 3 (60) | 2 (33) | 4 (100) | 3 (60) |
| Limb Dystonia | 0 (0) | 2 (22) | 3 (60) | 1 (16) | 3 (75) | 3 (60) |
| Limb Apraxia | 3 (60) | 3 (33) | 3 (60) | 2 (33) | 4 (100) | 3 (60) |
| Postural instability | 1 (20) | 0 (0) | 2 (40) | 1 (17) | 4 (100) | 2 (40) |
| Cortical sensory/neglect | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (40) |
| Met probable PSP-S criteria | 0 (0) | 0 (0) | 1 (20) | 0 (0) | 2 (50) | 0 (0) |
| Met probable CBD-S criteria | 0 (0) | 0 (0) | 3 (60) | 1 (16) | 4 (100) | 3 (60) |
Chi squared test performed
a
p< 0.05 PSP vs CBD.
*
Includes mild abnormalities such as decreased initiation, velocity, or amplitude of saccades.
ˆ
Indicates vertical movements were more impaired than horizontal movements (only one PSP case presented clear vertical supranuclear gaze palsy at 1yr follow-up and thus met PSP-S criteria). PSP-S, CBD-S: PSP, CBD, syndrome (It was possible for one subject to meet both sets of diagnostic criteria).