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. 2015 Oct 30;7(12):13372–13387. doi: 10.18632/oncotarget.5618

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Copyright: © 2016 Kim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Significant differences of the DFS according to the EPCAM expression status in 216 patients with MSI-high CRC (discovery cohort). B. Significant differences of the DFS according to the EPCAM expression status in 725 patients with CRC (validation cohort). C. In the stage-stratified survival analysis using the validation cohort, significant differences of the DFS according to the EPCAM expression status were also maintained in patients with stage III CRC (n = 258). D. In the treatment-stratified survival analysis using the validation cohort, significant differences of the DFS according to the EPCAM expression status were also maintained in patients with stage III or high-risk stage II CRC treated with 5-fluorouracil-based adjuvant chemotherapy (n = 377). In all Kaplan-Meier survival analyses, EPCAM-CL cases (n = 2 in the discovery cohort and n = 1 in the validation cohort) were excluded due to the extremely small sample size.