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. 2016 Feb 8;7(12):13634–13650. doi: 10.18632/oncotarget.7215

Figure 5. TRIM29 induces NPC cell migration and invasion.

Figure 5

A. Wound-healing assays show that S18-TRIM29 and 6-10B-TRIM29 cells had higher motility compared with that in control cells. Left, representative images taken at 0 hr and 24 hr after scratching. Right, quantification of cell migration results that are expressed as the mean ± SD of three independent experiments. **p < 0.01 by Student's t test. B. Cell invasion was evaluated using a matrigel invasion chamber. TRIM29 over-expression increased S-18 and 6-10B cell invasive capacity. Left, representative images of cells that migrated through the PET membrane (magnification 200 x). Right, quantification of cell invasion data. Results are expressed as mean ± SD of three independent experiments. ***p < 0.001 by Student's t test. C. Knockdown of endogenous expression of TRIM29 in 5-8F cells via siRNA transfection was confirmed by Western blot. D. Inhibition of TRIM29 expression leads to much reduced cell invasiveness in 5-8F cells.