Skip to main content
. 2016 Feb 13;7(12):14095–14111. doi: 10.18632/oncotarget.7374

Figure 2. Differential histopathologic features according to MLH1 promoter methylation status in CIMP-H CRC.

Figure 2

(Upper left) Typical mucinous histology in a case of MLH1-methylated CIMP-H CRC (H&E, ×100). (Upper right) Non-mucinous adenocarcinoma in a case of MLH1-unmethylated CIMP-H CRC (H&E, ×100). (Middle left) Intense peritumoral lymphoid reaction in a case of MLH1-methylated CIMP-H CRC (H&E, ×100). (Middle right) Absent peritumoral lymphoid reaction in a case of MLH1-unmethylated CIMP-H CRC (H&E, ×100). (Lower left) Active Crohn-like lymphoid reaction in a case of MLH1-methylated CIMP-H CRC. Note the large (> 1 mm) lymphoid aggregate (H&E, ×50). (Lower right) Inactive Crohn-like lymphoid reaction in a case of MLH1-unmethylated CIMP-H CRC. Note the small (< 1 mm) lymphoid aggregates (H&E, ×50).