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. 2016 Feb 13;7(12):14095–14111. doi: 10.18632/oncotarget.7374

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Copyright: © 2016 Kim et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Distinct features and precursors of the MLH1-methylated and unmethylated CIMP-H CRCs. B. A molecular pathogenetic model of CIMP-H CRCs based on different serrated precursor pathways. Abbreviations: CIMP-H, CpG island methylator phenotype-high; MSI, microsatellite instability; MSI-H, MSI-high; MSI-L, MSI-low; MSS, microsatellite stable; MMR, DNA mismatch repair; dMMR, MMR-deficient; pMMR, MMR-proficient; BRAF^mt, BRAF mutation or BRAF-mutated; KRAS^mt, KRAS mutation or KRAS-mutated; APC^mt, APC mutation; SSA/P, sessile serrated adenoma/polyp; TSA, traditional serrated adenoma; CIN, chromosomal instability.

A. Distinct features and precursors of the MLH1-methylated and unmethylated CIMP-H CRCs. B. A molecular pathogenetic model of CIMP-H CRCs based on different serrated precursor pathways. Abbreviations: CIMP-H, CpG island methylator phenotype-high; MSI, microsatellite instability; MSI-H, MSI-high; MSI-L, MSI-low; MSS, microsatellite stable; MMR, DNA mismatch repair; dMMR, MMR-deficient; pMMR, MMR-proficient; BRAF^mt, BRAF mutation or BRAF-mutated; KRAS^mt, KRAS mutation or KRAS-mutated; APC^mt, APC mutation; SSA/P, sessile serrated adenoma/polyp; TSA, traditional serrated adenoma; CIN, chromosomal instability.