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. 2016 Feb 9;7(12):14125–14142. doi: 10.18632/oncotarget.7288

Figure 7.

Figure 7

A. Western-blot analysis of LY75, Rb1 and COX2 protein expression in tumor tissues extracted from SCID mice, injected with the parental SKOV3 cells, the mock-transfected (Ctrl) cells, and the LY75 knockdown cells (sh-S3). B. Representative IHC images of LY75, E-cadherin, N-cadherin, Rb1, COX2 and Ki-67 expression in tumor tissues extracted from mice injected with the parental, Ctrl, and sh-S3 SKOV3 cells. C. Survival curves for mice injected with parental, Ctrl, and sh-S3 SKOV3 cells. The median survival of mice injected with the Ctrl cells (89 days, n = 8) was similar to the parental SKOV3 cells (86 days, n = 7). Survival of mice injected with the LY75 knockdown cells was significantly shorter than the vector control (40 days; p<0.0001, Log rank test).