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. 2016 Feb 12;7(12):14199–14206. doi: 10.18632/oncotarget.7348

Figure 6. Neurite outgrowth in hippocampal neurons from APP knock-out and APP knock-in mice.

Figure 6

(A) Confocal images of hippocampal neurons from APP knock-out mice grown on monolayer of NCAM-negative fibroblasts in the presence of secreted APP (left), and on monolayer of NCAM-positive fibroblasts in the absence of secreted APP (middle) or in the presence of secreted APP (right) in medium. (B) Quantification of neurite outgrowth from APP knock-out mice. Neurite length of hippocampal neurons grown on monolayer of NCAM-negative fibroblasts was set to 100%. (C) Confocal images of hippocampal neurons from APP knock-in mice grown on monolayer of NCAM-negative (middle) or NCAM-positive fibroblasts (right). Hippocampal neurons from wild type mice grown on monolayer of NCAM-negative fibroblasts (left) as the control. (D) Quantification of neurite outgrowth. Neurite length of hippocampal neurons from wild type mice grown on NCAM-negative fibroblasts L929 was set to be 100%. *p < 0.05, **p < 0.01.