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. 2016 Feb 12;7(12):14251–14258. doi: 10.18632/oncotarget.7350

Figure 1. Mutational analysis of 32 cases of myeloid neoplasm with isolated i(17q) (red, mutation; gray, wild-type; white, not tested).

Figure 1

Genes are segregated based on the biologic functional categories on the left. The upper panels denote the case number, diagnostic categories per 2008 WHO classification and clonal cytogenetic abnormalities. Case #31 could not be sub-classified. Isochromosome (17q) was detected on a post-allogeneic stem cell transplant sample that showed relapsed AML. The pre-transplant cytogenetic studies were diploid, and molecular studies were unavailable. The patient also had a history of breast carcinoma treated with chemotherapy. Cases 7, 9 and 31 (highlighted in lavender) also underwent whole-exome sequencing. *represents a non-R882 DNMT3A mutation. aCML, atypical chronic myeloid leukemia; AML, acute myeloid leukemia; AML MRC, AML with myelodysplasia-related changes; CMML, chronic myelomonocytic leukemia; ET, Essential thrombocythemia; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasm; MDS/MPN, myelodysplastic/myeloproliferative neoplasm; MDS/MPN-U, myelodysplastic/myeloproliferative neoplasm unclassifiable; MF, myelofibrosis; RAEB, refractory anemia with excess blasts; sAML, secondary AML; SCT, stem cell transplant.