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. 2016 Feb 13;7(12):14324–14335. doi: 10.18632/oncotarget.7365

Figure 4. NIR-PIT with Laser showed superior in vivo anti-tumor effects.

Figure 4

(A) Repeated Laser NIR-PIT led to more effective A431 tumor volume reduction than LED (Laser PIT group vs. LED PIT group at day 10: *p = 0.0175 < 0.05) (n = 10 mice in each treatment group; Laser PIT group or LED PIT group vs. control at day 12: **P = 0.0002 < 0.001, by Kruskal-Wallis test with post-test). The treatment regimen is shown below the graph. (B) Repeated NIR-PIT with Laser lead to lower bioluminescence activity within the tumor compared with LED (n = 10 mice in each treatment group; **P < 0.01, ***P < 0.05). The treatment regimen and time point of measurement of bioluminescence are indicated above the graph. (C) Bioluminescence images (BLI) of MDA-MB-468-luc orthotopic tumors in response to repeated NIR-PIT with LED or Laser. Typical images of a mouse that had almost the same RLU in both tumor regions before therapy is depicted. Laser irradiation was performed on the left side orthotopic tumor while LED irradiation was performed on the right side.