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. 2016 Feb 13;7(12):14324–14335. doi: 10.18632/oncotarget.7365

Figure 5. In vivo fluorescence imaging in response to repeated LED or Laser mediated NIR-PIT.

Figure 5

Fluorescence images were obtained at each time point before and after repeated NIR-PIT as indicated (A). In vivo fluorescence imaging of A431 xenografts (left for LED, right for Laser) (B) and MDA-MB-468-luc orthotopic breast tumors (right for LED, left for Laser) (C) tumor bearing mice treated with repeated NIR-PIT showed differences in fluorescence signal after LED and Laser irradiation (upper; high threshold, lower; low threshold). Tumors of almost the same size were selected for comparison (see magnified view). Ex vivo fluorescence images of A431 or MDA-MB-468-luc tumor (D) at 2 days after NIR-PIT also showed lower intensity with Laser than with LED. Tumor-to-background ratio (TBR) of the IR700-fluorescence intensity in A431 tumors or MDA-MB-468-luc orthotopic breast tumors (E) demonstrated quantitative differences in fluorescence (n = 10 mice in each treatment group; *P < 0.01, **P < 0.05).