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. 2016 Feb 13;7(12):14324–14335. doi: 10.18632/oncotarget.7365

Figure 6. Stronger SUPR effects are induced by Laser mediated NIR-PIT than LED.

Figure 6

The SUPR effect was evaluated by measuring fluorescence signals of pan-IR800 injected 1 day after NIR-PIT using pan-IR700 at each time point (A). In vivo fluorescence imaging of A431 xenograft (left for LED, right for Laser) (B) and MDA-MB-468-luc orthotopic breast tumor (right for LED, left for Laser) (C) tumor bearing mice evaluated for the SUPR effect showed differences in fluorescence signal between treatments with LED and Laser (upper; IR700, lower; IR800, SUPR effect). Tumors of the same size were selected (see magnified view). (D) IR800 signal intensity (IR800-SI) of NIR-PIT-treated tumors and background. IR800-SI in A431 tumors or MDA-MB-468-luc orthotopic breast tumors treated with LED or Laser showed stronger signals in Laser treated tumors (n = 10 mice in each treatment group; *P < 0.0001).