Table 1. Kinase profiling of Bakuchiol (20 μM).
Kinase | Activity | Kinase | Activity | Kinase | Activity | Kinase | Activity | Kinase | Activity | Kinase | Activity |
---|---|---|---|---|---|---|---|---|---|---|---|
Abl | 133 | CDK9/cyclin T1 | 94 | EGFR (T790M) | 119 | Lck | 71 | MST1 | 62 | Rsk2 | 93 |
ASK1 | 68 | CHK1 | 136 | EGFR (T790M, L858R) | 107 | LKB1 | 85 | mTOR | 108 | p38 | 51 |
Aurora-A | 66 | CHK2 | 97 | FAK | 100 | Lyn | 134 | NEK7 | 102 | SGK | 151 |
Blk | 47 | CHK2 (I157T) | 91 | Fgr | 98 | MAPK1 | 78 | p70S6K | 172 | SIK | 108 |
CaMKI | 85 | CHK2 (R145W) | 110 | Flt1 | 93 | MAPK2 | 113 | PDK1 | 75 | Src | 95 |
CaMKIIβ | 65 | cKit | 92 | Fyn | 102 | MEK1 | 87 | Pim-1 | 111 | Syk | 67 |
CDK1/cyclin B | 84 | CSK | 147 | GSK3β | 49 | Met | 70 | Pim-2 | 122 | WNK2 | 82 |
CDK2/cyclin A | 90 | c-RAF | 101 | Hck | 57 | MKK4 | 108 | Pim-3 | 80 | Yes | 134 |
CDK2/cyclin E | 76 | cSRC | 87 | IKKα | 148 | MKK6 | 94 | PKA | 120 | ZAP-70 | 102 |
CDK3/cyclin E | 100 | DAPK1 | 80 | JAK2 | 100 | MKK7β | 94 | PKBα | 109 | ||
CDK5/p25 | 94 | DDR2 | 97 | JAK3 | 79 | MLK1 | 59 | PKCα | 109 | ||
CDK5/p35 | 111 | EGFR | 111 | JNK1α1 | 98 | Mnk2 | 84 | Plk1 | 88 | ||
CDK6/cyclin D3 | 108 | EGFR (L858R) | 101 | JNK2α2 | 100 | MSK1 | 118 | ROCK-I | 84 | ||
CDK7/cyclin H | 105 | EGFR (L861Q) | 105 | KDR | 92 | MSK2 | 101 | Rsk1 | 80 |