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Growth inhibitory effect (5 days) of A–C. siHER2d75, D–F. trastuzumab, and G–I. lapatinib in BT474, HCC1954, and JIMT1 cells that had been pre-treated weekly with 1 nM of siHER2d75 (H15) or siControl (C15) for 15 weeks. J. HER2 signaling molecules in specified cell lines at 3 days after 10 nM siHER2d75 treatment. K. HER2 signaling molecules in BT474-C15 and BT474-H15 at 3 days after 10–50 μg/ml trastuzumab or 100-500 nM lapatinib treatment.
