Figure 9. Cytotoxicity of T-siHER2^d75-NP in a panel of non-tumorigenic cell lines, MCF10A, HEK293, HEPG2, and HUVEC.

A. Western blots indicate no detectable HER2 expression in these cell lines when compared to BT474. B. Low cytotoxicity (<10% cell death) of T-siHER2^d75-NP at efficacious dose (60 nM as siHER2^d75) compared to the drug benchmark, APAP (25 mM). Cell viability was measured at 24 h after the treatment and reported as the percentage of the untreated control.