Skip to main content
. 2016 Feb 19;7(12):14940–14950. doi: 10.18632/oncotarget.7496

Figure 5. The combined therapy of VNP-shABCB5 with CTX promotes cell death and inhibits cell proliferation.

Figure 5

A. Immunohistochemistry for Ki-67 (stained brown) revealed the expression of Ki67 in the tumors of mice treated with PBS, CTX, VNP-scrambled plus CTX, VNP-shABCB5 plus CTX. B. Quantification of Ki-67 expression. Data are presented as mean ± SD. *P < 0.05 for VNP-scrambled & CTX versus VNP-shABCB5 & CTX. C. TUNEL staining showed the death of B16F10 melanoma cells from the mice treated with PBS, CTX, VNP-scrambled plus CTX, VNP-shABCB5 plus CTX. D. Quantitative analysis of TUNEL-positive cells. Data are presented as mean ± SD. *P < 0.05 for VNP-scrambled & CTX versus VNP-shABCB5 & CTX.