Table 1. Body and liver weights after diclofenac treatment.
Duration | Dosage | Body weight (g) | Liver weight (g) | ||
---|---|---|---|---|---|
Before administration | After administration | Absolute weight (g) | Relative ratio (%) | ||
Day 1 | Vehicle | 22.86 ± 1.64 | 23.63 ± 1.24 | 1.13 ± 0.03 | 4.77 ± 0.18 (100) |
30 mg/kg | 21.16 ± 1.11 | 20.90 ± 0.14 | 1.08 ± 0.03 | 5.14 ± 0.12a (108) | |
Day 3 | Vehicle | 20.68 ± 0.86 | 22.48 ± 0.43b | 1.13 ± 0.03 | 5.02 ± 0.08 (100) |
30 mg/kg | 22.02 ± 1.02 | 22.84 ± 0.54 | 1.21 ± 0.03a | 5.31 ± 0.25 (106) | |
Day 14 | Vehicle | 24.62 ± 1.03 | 21.01 ± 1.22c | 0.92 ± 0.13 | 4.41 ± 0.72 (100) |
30 mg/kg | 24.80 ± 0.83 | 20.43 ± 0.84c | 1.05 ± 0.06 | 5.14 ± 0.18 (117) |
Values represent the means ± standard deviation (SD). The relative organ weight was calculated using the ratio of liver weight to body weight and is represented as a percentage of the total body weight.
P-values were calculated using the Student's t-test and significance is defined by
P < 0.05; vs. corresponding control vehicle.
P < 0.05; vs. corresponding before administration;
P < 0.01; vs. corresponding before administration.