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Intracellular oligonucleotide delivery to HeLa cells. (A) Gel electrophoresis of oligonucleotides—channels: (i) as-RNA, (ii) LyP-1-as-RNA conjugate (Compound 10), and (iii) as-RNA and LyP-1 peptide mixture 10. (B) Confocal micrographs showing expression of luciferase upon delivery of Compound 10. (C) as-RNA without LyP-1 conjugated to it causes no luciferase expression. (D) Dose–response curve for luciferase expression upon Compound 10 addition.
