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. 2016 Jul;148(1):43–63. doi: 10.1085/jgp.201611584

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© 2016 Mukhtasimova et al.

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Figure 2. — Improved temporal resolution of single channel currents. (A) Currents recorded from adult human muscle AChRs activated by 3 µM ACh with the Gaussian digital filter set to 10 kHz (top trace) and 25 kHz (bottom trace). Channel openings are upward deflections. Below each trace are the detected events using a threshold at half the unitary current amplitude. (B) Histogram of closed dwell times from the entire recording fitted by the sum of four exponential components. The component with shortest mean duration is shown by a thickened curve. The five shaded bins indicate the increase in resolved closed dwell times as the result of the increase in bandwidth from 10 to 25 kHz.