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. 2016 Jun 27;213(7):1319–1329. doi: 10.1084/jem.20151359

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© 2016 Renkema et al.

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Figure 2. — IL-4Rα expression is required for normal numbers of antigen-specific memory phenotype CD8⁺ T cell precursors. (A–D) Tetramer enrichment was performed on spleen and lymph nodes from individual age-matched WT BALB/cByJ and IL-4Rα KO BALB/cByJ using tetramers containing LCMV NP_118–126/L^d (labeled NP_118–126 Tet⁺) and L. monocytogenes LLO_91–99/K^d (labeled LLO_91–99 Tet⁺). The total numbers of tetramer-binding cells (A and C) and the numbers of cells in the indicated phenotypic subsets (B and D) are indicated. Each data point represents cells recovered from an individual mouse. Error bars indicate mean ± SD. P-values are represented as *, P < 0.05; **, P < 0.01; ****, P < 0.0001 by unpaired Student’s t test. Data are combined from two separate experiments (experiment 1: n = 5 for WT, n = 4 for IL-4Rα KO; experiment 2: n = 4 for WT, n = 4 for IL-4Rα KO) and are representative of four experiments (n = 15 for WT, n = 15 IL-4Rα KO in total).