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. 2016 Jun 27;213(7):1175–1183. doi: 10.1084/jem.20151966

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© 2016 Yoshikawa et al.

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Figure 4. — Lack of neuronal VEGFR2 leads to persistent hyaloid vessels. (A–R) Whole-mount or section staining of hyaloid vessels at P6 or P12 and quantification (n = 4). The amount of hyaloid vessels is increased in Vegfr2^Δneuro mice (arrowheads in F). The abundant endothelial apoptosis (arrowheads in I) and vessel regression (arrowheads in K) detected in control mice are greatly reduced in Vegfr2^Δneuro mice. (S–V) Whole-mount staining of the retinal vasculature. Premature intraretinal vascularization (arrowheads in V) are seen in Vegfr2^Δneuro mice. (W) Schematic diagram depicting vascular abnormalities in Vegfr2^Δneuro mice. Bars: (A, B, E, F, M, N, S, and T) 500 µm; (C, D, U, and V) 200 µm; (G–L) 50 µm. *, P < 0.05; **, P < 0.01; two-tailed Student’s t tests. Representative confocal images from four independent experiments (four mice per group) are shown. Data are represented as mean ± SD. ECs, endothelial cells; ColIV, collagen type four; Cont, control.