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Schematic diagram showing the proposed mechanism of MC-dependent myofilament Ca2+ sensitization after MI. MCs, originating primarily from WAT, infiltrate the heart after MI and regulate cardiac function via regulation of myofilament protein phosphorylation, cTnI, and MyBPC. The mechanism proposed involves tryptase-regulated PAR2 activation with subsequent Gi activation inhibiting cAMP/PKA activity. AC, adenylyl cyclase; p, phosphoryl group.
