TABLE 2.
Richness, α-Diversity, Relative Abundance, and Case–Control Status by Fecal Microbiota Profile
| Escherichia-Dominant Profile, n = 46 (30%) | Bifidobacterium-Dominant Profile, n = 32 (21%) | Enterobacter/Veillonella-Dominant Profile, n = 34 (22%) | Bacteroides-Dominant Profile, n = 43 (28%) | P | |
|---|---|---|---|---|---|
| Richness | |||||
| Number of genera, median (IQR) | 13 (10–17) | 15 (11–17) | 11 (9–14) | 20 (15–25) | <.001 |
| α-Diversity, median (IQR) | |||||
| Shannon index | 1.86 (1.20–2.46) | 1.96 (1.62–2.39) | 1.69 (1.35–2.20) | 2.51 (2.22–2.96) | <.001 |
| Relative abundance of 10 most abundant genera, mean (SD) | |||||
| Escherichia | 0.53 (0.22) | 0.12 (0.12) | 0.03 (0.08) | 0.13 (0.14) | .003a |
| Bifidobacterium | 0.12 (0.12) | 0.50 (0.19) | 0.07 (0.09) | 0.12 (0.12) | .003a |
| Enterobacter | 0.04 (0.10) | 0.06 (0.11) | 0.49 (0.26) | 0.08 (0.11) | .003a |
| Bacteroides | 0.03 (0.07) | 0.04 (0.07) | 0.04 (0.12) | 0.37 (0.23) | .003a |
| Veillonella | 0.03 (0.05) | 0.02 (0.05) | 0.15 (0.19) | 0.02 (0.05) | .003a |
| Lachnospiraceae incertae sedis | 0.07 (0.12) | 0.02 (0.04) | 0.04 (0.10) | 0.07 (0.09) | .85a |
| Streptococcus | 0.02 (0.04) | 0.05 (0.11) | 0.03 (0.06) | 0.01 (0.01) | .49a |
| Clostridium sensu stricto 1 | 0.04 (0.08) | 0.00 (0.01) | 0.03 (0.05) | 0.01 (0.02) | .20a |
| Enterococcus | 0.02 (0.04) | 0.02 (0.04) | 0.02 (0.05) | 0.01 (0.02) | .96a |
| Akkermansia | 0.00 (0.02) | 0.03 (0.09) | 0.03 (0.11) | 0.01 (0.08) | .99a |
| Case–control status | .01 | ||||
| Bronchiolitis | 10 (22%) | 6 (19%) | 5 (15%) | 19 (44%) | |
| Healthy control | 36 (78%) | 26 (81%) | 29 (85%) | 24 (56%) | |
a
Benjamini–Hochberg adjusted P value accounting for multiple comparisons.