Figure 6. Effect of Akt/mTOR and ERK pathway inhibition on the GDF-15-induced increase in Ca_v1.3 α subunit expression.

(A and B) Western blot and statistical analyses of the effects of the Akt inhibitor LY294002 and mTOR inhibitor rapamycin (A) and the MEK inhibitor U0126 (B) on GDF-15-induced up-regulation of Ca_v1.3 protein levels. Results are means±S.E.M. *P<0.05 for the two groups connected with a straight line.