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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Obesity (Silver Spring). 2016 May 13;24(7):1480–1488. doi: 10.1002/oby.21504

Figure 1.

Figure 1

Model of DIO replicates human obesity. Changes in (A) body weight (B) fat mass measured by EchoMRI and (C) glucose tolerance test in mice fed a high fat diet (HFD) or standard control diet (CD) for 6 weeks. Values are means ± SEM. *p<0.05 vs normal diet. n=12–16/group. White boxes=Normal diet, Black boxes = HFD. (D) Obese mice have higher mortality after sepsis. Mice were randomized to a HFD or ND for 6–7wks. CLP was performed and survival was monitored. Animals were censored at 30h. p=0.035 by log-rank test, n=12/group. White diamonds = Normal diet, Black boxes = HFD.