Table 1. Clinicopathologic Factors of 109 Patients for Whom 2-Stage Hepatectomy Was Planned.
| Characteristic | Only first-stage resection completed (n=20) | Second-stage resection completed (n=89) | p Value |
|---|---|---|---|
| Median age, y (range) | 51 (26-68) | 52 (23-72) | 0.416 |
| Sex, n (%) | 0.680 | ||
| Male | 14 (70) | 58 (65) | |
| Female | 6 (30) | 6 (30) | |
| Primary tumor location, n (%) | 0.642 | ||
| Colon | 16 (80) | 75 (84) | |
| Rectum | 4 (20) | 14 (16) | |
| Primary tumor nodal status, n (%) | 0.650 | ||
| Positive | 14 (70) | 58 (65) | |
| Negative | 2 (10) | 12 (14) | |
| Unknown | 4 (20) | 19 (21) | |
| Synchronous presentation of CLM, n (%) | 19 (95) | 74 (83) | 0.176 |
| Combined primary resection at first-stage*, n (%) | 4 (20) | 21 (24) | 0.730 |
| Extrahepatic metastases at time of first-stage resection, n (%) | 0 | 16 (18) | 0.040 |
| No. of CLM on preoperative imaging, median (range) | 9 (4-60) | 6 (2-25) | 0.004 |
| Median diameter of largest metastasis on preoperative imaging, mm (range) | 45 (18-120) | 29 (10-144) | 0.011 |
| Median no. of cycles of chemotherapy before first-stage resection (range) | 10 (3-26) | 6 (1-24) | 0.006 |
| Interval chemotherapy administered after first-stage resection, n (%) | 19 (95) | 39 (44) | <0.001 |
| Positive margin on first- or second-stage resection, n (%) | 2 (10) | 22 (25) | 0.150 |
| Portal vein embolization, n (%) | 18 (90) | 62 (70) | 0.063 |
| RAS mutation†, n (%) | 8 (40) | 32 (36) | 0.378 |
| Pathological response on final resection (first- or second-stage), n (%) | |||
| Complete | NA | 5 (5.5) | NA |
| Major | 22 (24.5) | ||
| Minor | 37 (42) | ||
| Unknown | 25 (28) |
*
In addition, only one patients underwent a combined primary resection at time of second stage.
†
Sixteen patients (15%) did not undergo evaluation of RAS mutation status, and no patient had NRAS mutations.
CLM, colorectal liver metastases.