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. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: J Am Coll Surg. 2016 Jan 18;223(1):99–108. doi: 10.1016/j.jamcollsurg.2015.12.057

Table 4. Risk Factors for Major Complications with 2-Stage Hepatectomy.

Risk factor	Univariate p value	Multivariate*
		Odds ratio	95% Confidence interval		p Value
		Odds ratio	Lower	Upper	p Value
Rectal primary tumor	0.052	3.904	1.248	12.211	0.019
Primary tumor nodal status positive	0.347
Synchronous presentation of CLM	0.081	0.295	0.091	0.953	0.041
> 5 CLM^†	0.295
Diameter of largest metastasis > 5 cm^†	0.701
> 6 cycles of chemotherapy before first-stage resection	0.9
Bevacizumab before first-stage resection	0.468
Interval chemotherapy after first-stage resection	0.875
Combined primary surgery at first-stage resection	0.763
Portal vein embolization	0.474
> 1 lesion resected during first-stage resection	0.028	3.594	1.313	9.842	0.013
> 1 lesion resected during second-stage resection	0.225
RAS mutation	0.308

^*

Binary logistic regression, using enter method with 0.1 selection.

^†

Based on computed tomography before chemotherapy.

CLM, colorectal liver metastases.