Table 3.
Adipose tissue expression of genes encoding mediators of inflammation at baseline (pre-intervention) and after 7% weight loss following either Roux-en-Y gastric bypass surgery (RYGB) or an intensive lifestyle modification combined with best medical care (‘Lifestyle’)4.
| Baseline (pre-intervention) | Follow-up (7% wt loss) | RM-ANOVA | ||
|---|---|---|---|---|
| P (time) | P (time × intervention) | |||
| Tumor necrosis factorα (TNFα) | ||||
| Lifestyle (n=7) | 9.1 (9.0 – 10.8) | 10.2 (9.9 – 10.7) | 0.351 | 0.636 |
| RYGB (n=6) | 10.3 (9.5 – 14.3) | 11.1 (9.7 – 19.8) | ||
| Interleukin-1β (IL1B) | ||||
| Lifestyle (n=7) | 4.1 (3.5 – 4.9) | 9.3 (7.4 – 21.5) | 0.037 | 0.926 |
| RYGB (n=6) | 4.6 (3.3 – 8.6) | 8.8 (4.3 – 12.4) | ||
| Interleukin-6 (IL6) | ||||
| Lifestyle (n=7) | 8.5 (7.7 – 16.2) | 10.9 (8.8 – 12.0) | 0.597 | 0.726 |
| RYGB (n=6) | 9.5 (6.8 – 14.1) | 12.6 (9.7 – 16.2) | ||
| Monocyte Chemoattractant Protein-1 (MCP1) | ||||
| Lifestyle (n=7) | 820 (748 – 870) | 602 (436 – 657) | 0.229 | 0.734 |
| RYGB (n=6) | 807 (520 – 1,055) | 629 (559 – 920) | ||
| Intercellular adhesion molecule-1 (ICAM1) | ||||
| Lifestyle (n=7) | 79 (76 – 88) | 86 (74 – 93) | 0.727 | 0.460 |
| RYGB (n=6) | 96 (72 – 103) | 91 (67 – 101) | ||
| Adiponectin (ADIPOQ) | ||||
| Lifestyle (n=7) | 24,473 (20,205 – 25,527) | 19,960 (19,373 – 22,983) | 0.010 | 0.125 |
| RYGB (n=6) | 20,436 (19,559 – 21,232) | 15,680 (12,583 – 18,856) | ||
3 Values are medians (25th, 75th percentiles), in mRNA copy number of the respective target gene per ng of total RNA, normalized by a normalization factor based on two housekeeping genes, β-glucuronidase and 18s ribosomal RNA. RM-ANOVA: Repeated measures analysis of variance.