Table 2.

Association of candidate gene polymorphisms with KT ratio^a.

SNPb	Exp(Beta)c	95% CI	P	Location	MAF	Gene
rs17200810d	1.65	(1.35, 2.02)	1.41×10−6	3’	0.02	TNF
rs34451538	1.50	(1.26, 1.79)	3.90×10−6	5’	0.03	TNF
rs276565e	1.11	(1.06, 1.16)	5.30×10−6	5’	0.28	IFNGR1f
rs114064880	1.71	(1.36, 2.16)	5.33×10−6	5’	0.01	TNF
rs11575838	1.68	(1.34, 2.11)	7.13×10−6	3’	0.01	TNF
rs2770148g	1.15	(1.08, 1.23)	2.94×10−5	Intron 2	0.12	TLR4

Abbreviations: KT, kynurenine/tryptophan ratio; SNP, single nucleotide polymorphism; CI, confidence interval; MAF, minor allele frequency.

^aLinear mixed effects regression models of log₁₀plasma KT ratio were adjusted for gender, pregnancy, cohort (ARKS vs. UARTO), and the first ten principal components.

^bGenotyped or imputed single nucleotide polymorphism.

^cFold change in KT ratio (nM/μM) per copy of minor allele.

^dGenotyped SNP, multiple transcription factors predicted to bind to this loci (e.g. IRF4, JUND; RUNX).

^eGenotyped SNP, in active H3K27Ac mark regulatory region.

^fThis SNP also lies 100 kb upstream of IL20RA and 43 kb downstream of IL22RA2.

^gIn linkage disequilibrium (LD) with genotyped SNP, rs1413088.