Table 3.
Association of polymorphisms with plasma KT ratio from genome-wide analysisa.
| SNPb | Exp(Beta)c | 95% CI | P | Location | MAF | Nearest Gene(s) |
|---|---|---|---|---|---|---|
| rs56185965 | 1.55 | (1.33, 1.79) | 8.73×10−9 | intergenic | 0.02 | CSPG5; ELP6 |
| rs6950107d | 1.44 | (1.26, 1.64) | 7.14×10−8 | intron 6 | 0.03 | PTPRN2 |
| rs17085469 | 1.20 | (1.13, 1.29) | 7.75×10−8 | 5’ | 0.10 | RP11-736G13.1 |
| rs13041834e | 1.17 | (1.10, 1.25) | 3.13×10−7 | intergenic | 0.12 | CYP24A1; BCAS1; MIR4756 |
| rs75257475f | 1.23 | (1.13, 1.32) | 2.95×10−7 | intron 1 | 0.07 | PTPRM |
| rs200564710 | 1.30 | (1.18, 1.44) | 3.20×10−7 | intergenic | 0.05 | HOMER1; PAPD4 |
| rs114598920 | 1.37 | (1.21, 1.54) | 3.73×10−7 | intron 1 | 0.03 | CLSTN2 |
| rs115718192 | 1.61 | (1.34, 1.93) | 4.13×10−7 | intergenic | 0.02 | TFRC; SDHAP1 |
| rs76101033 | 1.41 | (1.23, 1.61) | 4.29×10−7 | Intron 2 | 0.02 | RP11-6757F12.1 |
Abbreviations: KT, kynurenine/tryptophan ratio; SNP, single nucleotide polymorphism; CI, confidence interval; MAF, minor allele frequency.
a
Linear mixed effects regression models of log10plasma KT ratio were adjusted for gender, pregnancy, cohort (ARKS vs. UARTO), and the first ten principal components.
b
Genotyped or imputed single nucleotide polymorphism.
c
Fold change in KT ratio (nM/μM) per copy of minor allele.
d
SNP predicted to decrease binding to SMAD3.
e
SNP in active H3K27Ac mark region, in linkage disequilbrium (LD) with genotyped SNP, rs6064045.
f
SNP predicted to alter binding to FOSL2, in LD with 11 other SNPs with P<1×10−7, including genotyped SNP rs1695225.