Table 2.
Incidence rates and Cumulative Incidence for new-onset moderate-to-severe depressive symptoms based on the Beck Depression Inventory (BDIa score ≥17) by detectable CSF HIV RNA (≥50 copies/ml) and using discrete-time survival models (N=154).
| New-onset moderate-to-severe depressive symptoms | |||||
|---|---|---|---|---|---|
| No. of Subjects at Study Entry (N) |
Time at Risk (Person-months) |
No. of Events |
Incidence rate (IR) per 1,000 person-months |
||
| IR | 95% CI | ||||
| Entire study cohort | 154 | 2,496 | 24 | 9.6 | (6.4, 14.3) |
| CSF HIV RNA | |||||
| Undetectable | 124 | 2,190 | 18 | 8.2 | (5.2, 13.0) |
| Detectable | 30 | 306 | 6 | 19.6 | (8.8, 43.6) |
a
BDI: Beck depression inventory II - depression severity scores: 0–9, minimal; 10–16, mild; 17–29, moderate; 30–63, severe; CSF HIV RNA detectable at ≥50 copies/ml
Markov transition matrix probability that persons on cART with detectable CSF HIV RNA at prior visit, would present with undetectable CSF HIV RNA at the next subsequent visit is 45.8%.