ITC analysis of B. japonicum Mur and E. coli Fur titrated with Mn2+ or Fe2+.
ITC raw data collection trace for titration of (A) Mn2+ to a sample of B. japonicum Mur, (B) Fe2+ to a sample of B. japonicum Mur, (C) Mn2+ to a sample of E. coli Fur, and (D) Fe2+ to a sample of E. coli Fur. (E) Dissociation binding constant (Kd) values and calculated number of sites per monomer (N) of B. japonicum Mur and E. coli Fur for Mn2+ and Fe2+ were determined using a one-binding-site model fitted to the titration data taken in triplicate.