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. Author manuscript; available in PMC: 2016 Nov 16.
Published in final edited form as: Nat Genet. 2016 May 16;48(7):803–810. doi: 10.1038/ng.3572

Figure 2. Power gain by weighting SNPs by allele frequency and effect size.

Figure 2

We compared the statistical power of BUHMBOX with a weighting scheme that optimally weights correlations between SNPs (weighted) to an alternative approach that weights correlations uniformly (unweighted; equation (12) in Supplementary Note). We simulated 1,000 case individuals and assumed 50 risk loci, whose OR and RAFs were sampled from the GWAS catalog. Colored bands denote 95% confidence intervals of power estimates.